Evaluation of the Extracellular Matrix as a potential prognostic marker for patients with Glioblastoma IDH-wild type

Authors

DOI:

https://doi.org/10.61229/mpj.v2i1.42

Keywords:

Glioblastoma, Colágeno, biomarcador, Matriz Extracelular, Microambiente Tumoral, Glioblastoma, Collagen, biomarker, Extracellular Matrix, Tumor Microenvironmen

Abstract

Although the extracellular matrix (ECM) accounts for 20% of brain volume, collagen is present at low levels, mainly in perivascular regions. In the CNS, tissue repair occurs through gliosis, without abundant collagen production. In glioblastomas (GBM), collagen gene expression increases and the ECM is altered, influencing tumor adhesion, invasiveness, and recurrence. Collagen signatures may be prognostic markers in GBM patients. Studies demonstrate that microenvironmental reorganization, including collagen deposition, is crucial for GBM progression.

This study, involving 50 patients with GBM IDH-wild type, aims to evaluate the potential of ECM as a prognostic indicator. Through the analysis of tumor samples with stainings for ECM and type III collagen, the impact of ECM deposition and collagen architecture on patient survival will be assessed and a survival prediction model will be proposed using these factors. It is expected that the analysis of collagen deposition will allow the identification of patterns associated with survival in GBM patients and contribute to the understanding of the role of ECM in GBM progression as a potential prognostic biomarker.

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Author Biographies

Karla Cândida Pereira, Faculdade de Minas Gerais -FAMINAS- BH e Instituto Mário Penna

Medical student at FAMINAS and scientific initiation student at the Teaching, Research and Innovation Center of the Mário Penna Institute.

Leonardo Augusto Wendling Henriques, Hospital Luxemburgo

PhD, neurosurgeon at the Luxembourg Hospital of the Mário Penna institute

Paulo Guilherme de Oliveira Salles, Mário Penna Institute

PhD, pathologist at Hospital Luxemburgo and Scientific Director of the Teaching, Research and Innovation Center at the Mário Penna Institute.

Izabela Ferreira Gontijo de Amorim , Faculdade de Minas Gerais -FAMINAS- BH e Instituto Mário Penna

PhD, Professor of Medicine at the Faculty of Minas Gerais-FAMINAS and researcher at the Research and Innovation Teaching Center at the Mário Penna Institute.

Letícia da conceição Braga , Instituto Mário Penna

PhD, Translational Research Manager at the Teaching, Research and Innovation Center at Instituto Mário Penna.

References

Dapash M, Hou D, Castro B, Lee-Chang C, Lesniak MS. The Interplay between Glioblastoma and Its Microenvironment. Cells. 2021; 10(9):2257. doi: 10.3390/cells10092257. PMID: 34571905; PMCID: PMC8469987. DOI: https://doi.org/10.3390/cells10092257

Pointer KB, Clark PA, Schroeder AB, Salamat MS, Eliceiri KW, Kuo JS. Association of collagen architecture with glioblastoma patient survival. J Neurosurg. 2017 Jun;126(6):1812-1821. doi: 10.3171/2016.6.JNS152797. Epub 2016. PMID: 27588592; PMCID: PMC5386834. DOI: https://doi.org/10.3171/2016.6.JNS152797

Hoogstrate Y, Draaisma K, Ghisai SA, van Hijfte L, Barin N, de Heer I, et al. Transcriptome analysis reveals tumor microenvironment changes in glioblastoma. Cancer Cell. 2023; 41(4):678-692.e7. doi: 10.1016/j.ccell.2023.02.019. Epub 2023 Mar 9. PMID: 36898379. DOI: https://doi.org/10.1016/j.ccell.2023.02.019

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Published

2024-08-16

How to Cite

Cândida Pereira, K., Wendling Henriques, L. A., de Oliveira Salles, P. G., Ferreira Gontijo de Amorim , I., da conceição Braga , L., & Alencar, R. (2024). Evaluation of the Extracellular Matrix as a potential prognostic marker for patients with Glioblastoma IDH-wild type. Mário Penna Journal, 2(1), 125–127. https://doi.org/10.61229/mpj.v2i1.42

Issue

Vol. 2 No. 1 (2024): Mário Penna Journal

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Artigos

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